Zirgan eye gel instructions analogues. Zirgan eye gel: instructions for use and reviews. Zirgan eye gel: composition

Zirgan is an eye gel with an antiviral effect, an analogue of acyclovir. It is used in ophthalmology in the treatment of acute superficial keratitis.

Composition and release form

Zirgan - sterile colorless eye gel, contains:

• Active ingredient: ganciclovir - 1.5 mg;
• Excipients: carbomer, benzalkonium chloride, sorbitol, sodium hydroxide, water.

Package. White plastic tubes of 5 grams each with a dispenser tip and a removable stand for storing the packaging upside down in a cardboard box.

Pharmacological properties

Zirgan eye gel is active antiviral agent. Its main substance, ganciclovir, is structurally close to acyclovir and is a synthetic analogue of guanine.

Ganciclovir is a nucleoside that can inhibit the replication of human herpes simplex viruses types I and II. Penetrating into infected cells, ganciclovir is synthesized to its active form - ganciclovir triphosphate. Moreover, the level of ganciclovir triphosphate in uninfected cells is 10 times lower.

The antiviral activity of ganciclovir triphosphate is manifested by inhibition of viral DNA synthesis through competitive blocking of viral DNA polymerase, as well as direct inclusion in the viral DNA chain, preventing its replication.

The drug is active against cytomegalovirus, Epstein-Barr virus, Herpes simplex and Varicella zoster viruses.

Indications for use

Therapy of acute superficial keratitis caused by the human herpes simplex virus.

Directions for use and doses

The standard dosage for the treatment of acute viral keratitis is 1 drop of Zirgan gel into the affected eye conjunctivally 5 times a day. After reepithelialization of the cornea, the frequency of instillations is reduced to 3 times a day. The duration of treatment at this dosage is 7 days.

The full course of treatment is 21 days.

Contraindications

• Reactions of individual intolerance to acyclovir or its derivatives.
• Age up to 12 years.
• Pregnancy, lactation.

Side effects

Irritation of eye tissue, redness of the conjunctiva, punctate keratitis, blurred vision.

Overdose

There is no reliable information.

Drug interactions

Not described.

special instructions

Due to the identified genotoxicity of the drug Zirgan, men and women are recommended to use reliable contraceptive measures during the treatment period. As well as 3 months after the end of treatment.

Benzalkonium chloride, included in Zirgan Eye Gel, is a preservative that can accumulate in soft contact lenses, changing their color and causing eye irritation. Therefore, before applying the gel, the lenses must be removed and returned only after 15 minutes have passed from the moment of instillation.

Zirgan gel, when introduced into the eye, can cause blurred vision, which can be dangerous for patients driving a car or working with moving machinery.

The tube with Zirgan gel is stored upside down. room temperature. Keep away from children. The shelf life of the drug in unopened original packaging is 3 years.

Once opened, the gel is good for no more than 4 weeks.

Price of the drug Zirgan gel

The cost of the drug "Zirgan Gel" in Moscow pharmacies starts from 305 rubles.

Analogues of Zirgan gel

By contacting the Moscow Eye Clinic, you will be able to undergo an examination using the most modern diagnostic equipment, and based on its results, receive individual recommendations from leading specialists on the treatment of identified pathologies.

For diseases of the visual organs, ointments, drops and other topical medications are used. "Zirgan" is an eye gel with antiviral properties. The composition of the drug includes elements that are capable of attacking viral cells in a short period of time, destroying them. Before using the medicine, you should consult an ophthalmologist.

Composition and properties

Eye gel "Zirgan" ("Virgan") is a medication that has an antiviral effect that can fight Herpes Simplex, Epstein-Barr, and Varicella Zoster viruses.

The active component is ganciclovir - an element that is similar in structure to acyclovir and is a synthetic analogue of guanine. The medicine is produced in plastic tubes, 5 g each, equipped with dispensers in the form of tips and stands for proper storage medications in original packaging. Auxiliary components are:

• sorbitol;
• benzalkonium;
• water;
• carbomer, etc.

The action of the drug is aimed at eliminating the virus.

Ganciclovir is a nucleoside. It can inhibit the replication of human herpes simplex viruses types I and II. Upon penetration into diseased areas, the cells transform the active component to its active state - ganciclovir triphosphate. Activity against viruses consists of the ability to inhibit the synthesis of viral DNA polymerase with subsequent inclusion in the pathogen gene and the effect on chain termination, which prevents its replication. As a result, the ability to reproduce is stopped and herpes does not spread in the body, but is transferred to a latent form. Thanks to the auxiliary components, the gel acquires the necessary consistency, is successfully released during use and is able to fight viruses.

Indications

Zirgan eye gel is used to treat acute superficial keratitis caused by the herpes simplex virus, accompanied by the following symptoms:

• blepharospasm - narrowing of the eye slit;
• photophobia;
• itching in the eye area;
• feeling of a foreign body;
• lacrimation;
• cutting pain in the eye.

Contraindications

A person may not tolerate the drug due to his own characteristics.

The drug "Zirgan" should not be used in the following situations:

• personal intolerance to ganciclovir;
• period of pregnancy, lactation;
• therapy for cytomegalovirus infections of the retina;
• age up to 12 years.

In case of immunodeficiency, the drug should be used with extreme caution. During pregnancy and breastfeeding“Zirgan” is strictly unacceptable to use. Experiments have shown that this medicine characterized by genotoxicity. As a result, all people in reproductive condition must take this fact into account when using the medication and for the next 3 months after therapy. During this period, proven contraceptives must be used.

Instructions for use

Zirgan gel is available only by prescription, so before using it you must consult an ophthalmologist. Instructions for use indicate that the medication is administered into the area of ​​the lower conjunctival sac, 1 drop up to 5 times a day. Therapy must be carried out until the cornea is completely restored. In the next 7 days, this ointment should be administered three times a day, 1 drop. The total duration of the course of therapy is up to 3 weeks.

When treating with Zirgan gel, it is advisable to drink a lot of fluids to speed up the elimination of all components of this drug from the body.

Herpes simplex types 1 and 2 can even affect the eyes. However, today ophthalmologists have in their arsenal a fairly effective topical remedy that can resist it, and this is ganciclovir in the form of a gel. It is produced under the brand name Zirgan and is more effective in comparison with analogues based on acyclovir.

Composition of the gel and the role of its components

Zirgan contains 1.5 mg of the active substance - ganciclovir. The latter exhibits an antiviral effect due to its structure, similar to acyclovir. Ganciclovir is a laboratory-produced guanine analogue. Once inside an infected cell, it is converted into triphosphate, that is, into its active form. Moreover, its concentration in healthy cells is 10 times less.

What is the principle of its antiviral action? It suppresses herpes DNA synthesis in two ways:

1. Competitively reduces the activity of DNA polymerase (an enzyme without which the construction process is impossible) of the virus.
2. Directly incorporated into viral deoxyribonucleic acid, disrupting chain termination and preventing its replication.

Zirgan also contains excipients. Benzalkonium chloride acts as a preservative and antiseptic.

Thus, a bottle of gel can be stored for a relatively long time (3 years, and after opening - 4 weeks), while remaining safe for use.

Carbomer, also included in Zirgan, is an excellent humectant and thickener, forming stable emulsions in combination with water. Actually, thanks to him, Zirgan keeps its gel shape. It also contains sorbitol, sodium hydroxide, and water. They all play a role in creating the consistency and shape of the drug, and also affect the release of the active substance.

Diseases for which Zirgan is prescribed

The instructions indicate only one indication - superficial, caused by herpes simplex. It is not prescribed for CMV infections. Also, medicine still does not know whether treatment with Zirgan eye gel for keratoconjunctivitis that was caused by other types of viruses will be effective.

Mode of application

Ophthalmologists prescribe local treatment with Zirgan according to the following scheme: 1 drop. 5 rub. per day until the cornea is epithelialized again, then 1 drop. three times a day for 7 days. The course of treatment should not last more than 21 days.

How to apply the gel? It is simply instilled into the lower conjunctival sac of the infected organ.

Contraindications and precautions

Zirgan eye gel is not prescribed for:

• in case of hypersensitivity to ganciclovir or excipients;
• if you are allergic to acyclovir;
• pregnant women;
• when feeding a baby with breast milk;
• children under 12 years of age.

It is worth focusing attention on the fact that even non-pregnant women of childbearing age and men stand during treatment with Zirgan and for 3 months. after using contraception due to the genotoxicity of the drug. That is, it can negatively affect the hereditary material, affecting sperm and eggs.

Benzalkonium chloride can cause irritation and also affect the color of soft contact lenses. Therefore, the latter should be removed during instillation and put on only after 15 minutes after the procedure.

Zirgan is prescribed exclusively by a doctor and is released by pharmacists and pharmacists only with a prescription.

Zirgan - antiviral medicinal product, which is used in ophthalmic practice, the medication is used topically. Let's take a look at its instructions for use.

Composition and release form

The drug Zirgan is presented as a colorless eye gel, it has a uniform consistency. His active substance- ganciclovir at a dosage of 1.5 milligrams. The auxiliary components of the medication will be as follows: benzalkonium chloride, as well as sodium hydroxide, carbomer is added in the required amount, and sorbitol is also present, in addition, purified water.

The gel is placed in small tubes in an amount of five grams; a convenient tip and screw cap are included with the medicine. The medicine is packed in cardboard packaging. The drug is sold by prescription.

The drug is valid for three years from the date of release; after the container is opened, it can be stored for four weeks, after which the drug will lose its therapeutic effect, therefore, its further use should be abandoned.

pharmachologic effect

The drug Zirgan is intended for local use in ophthalmology. The active compound ganciclovir is a nucleoside that inhibits the replication of herpes simplex viruses. Directly in infected cells, the active substance is converted to ganciclovir triphosphate. The antiviral activity of the drug is to suppress the synthesis of viral DNA.

Indications for use

The medicine Zirgan is prescribed for the treatment of acute superficial keratitis caused by the herpes simplex virus. Before using the gel directly, you will need to consult an ophthalmologist.

Contraindications for use

Among the contraindications to the use of an ophthalmic agent are the following conditions:

The gel is not used during pregnancy;
The drug is not prescribed in pediatrics, in particular before the age of twelve;
The drug is not prescribed during breastfeeding.

In addition, the gel is contraindicated if the patient has a hypersensitivity to the compound ganciclovir or to other components medication.

Application and dosage

The drug is used locally, and the gel is carefully applied into the lower conjunctival sac of the diseased eye, one drop at a time, the frequency of use can be up to five times a day, and treatment is carried out until the function of the cornea improves, and then the frequency of use of the medication is reduced to three times a day .

In general, the duration of therapy with Zirgan can last no more than 21 days, and before starting treatment it is necessary to consult with a qualified ophthalmologist.

Overdose

There is no information about an overdose of Zirgan. If the gel is accidentally ingested, then the patient should undergo gastric lavage, after which a doctor should be consulted, especially in a situation where the patient feels uncomfortable.

Side effects

While using the ophthalmic drug Zirgan, you may develop side effects directly from the organ of vision, while local manifestations will be as follows: most often the patient will notice some blurred vision, eye irritation is added, the development of punctate keratitis is possible, in addition, pronounced redness of the conjunctiva occurs.

No systemic side effects have been reported to date. If the listed symptoms are severe, in this situation it is recommended to consult an ophthalmologist in a timely manner.

special instructions

The drug Zirgan is not intended for the treatment of cytomegalovirus infection localized on the retina.

It is worth noting that the benzalkonium chloride included in the gel can lead to some eye irritation, in addition, the color of soft contact lenses changes, therefore, the drug should not be allowed to come into contact with the lenses.

During treatment with Zirgan, the patient is not recommended to drive a vehicle, as there may be a temporary disturbance in visual perception, which gradually disappears after the end of therapeutic measures.

If the gel loses its physical and chemical properties, that is, it becomes liquid or too thick, in addition, it changes color, and is also heterogeneous, and so on, in this situation, from using such dosage form worth abstaining. It is worth noting that the drug cannot be frozen.

Analogs

Analogs include the drug Ganciclovir, as well as the drug Cymevene.

Conclusion

We reviewed the drug Zirgan, instructions for use, application, indications, contraindications, action, side effects, analogues, composition, dosage. Treatment of eye diseases should be carried out after prior consultation with a qualified ophthalmologist. If side effects occur during therapeutic measures, then the patient should urgently consult a doctor regarding further use of the medication.

As well as additional components such as benzalkonium chloride, water, sodium hydroxide.

Release form

In pharmacies, this product is sold in the form of an eye gel.

pharmachologic effect

Zirgan eye gel belongs to antiviral drugs.

Pharmacodynamics and pharmacokinetics

The active component of the drug is sequentially biotransformed into monophosphate with the participation cellular deoxyguanosine kinase , and after that to active ganciclovir triphosphate . It acts as a substrate and is incorporated into viral DNA , and then prevents its synthesis. It causes doom viruses .

In uninfected cells the content ganciclovir triphosphate 10 times less.

This drug is active against Varicella zoster, cytomegalovirus, virusEpstein-Barr, Herpes simplexI And Type II .

Indications for use

Zirgan eye gel is used in the treatment of acute superficial, which is caused by Herpes simplex virus .

Contraindications

Do not use the drug if the body is hypersensitive to its components. In addition, it is contraindicated for children under 12 years of age.

Side effects

As a rule, side effects appear on the organs of vision. This may include a burning and tingling sensation in the eyes, as well as superficial mottled keratitis .

Instructions for use (Method and dosage)

For patients prescribed Zirgan, eye gel should be instilled into inferior conjunctival sac . This should be done 5 times a day, 1 drop until reepithelialization cornea of ​​the affected eye. After this, the drug is used 3 times a day, 1 drop, for 7 days. The course of treatment should not last longer than 21 days.

Overdose

Data on overdose are not provided.

Interaction

Meaningful drug interactions not detected with other agents.

Terms of sale

The drug is sold strictly according to a doctor's prescription.

Storage conditions

The medicine should be kept away from children and stored at temperatures up to 25°C.

Best before date

Shelf life – 3 years. Once the tube is opened, it can be used for a maximum of 4 weeks.