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Depending on the degree and location of the infection, as well as for convenience, the doctor may prescribe the most different shapes and dosage of the drug. The dentist must describe in detail how to use them, but the main points are indicated in the instructions.
- Capsules - Take 500 mg of Lincomycin capsules three times a day. The doctor should tell you how many days to take the drug, taking into account the patient’s condition and other nuances. Children need to calculate the amount of medicine depending on their weight. So, per kilogram of a child’s weight, take 30-60 mg of antibiotic and break down the total daily norm for several appointments. It is recommended to take the drug two hours before or after a meal, since food affects the absorption of the drug. The more full you are and the closer to a meal you take the capsule, the worse the antibiotic will be absorbed.
- Ampoules - this method of application provides a faster and more effective effect, but symptoms may occur. side effects. Injections can be prescribed either intramuscular or intravenous. Injections into the gums are practically not used. If this is intravenous administration, then the medicine should be diluted with isotonic saline solution or glucose. For 600 mg of the drug, give 300 ml of solution. It is important to observe the frequency of injections - do them every 8 hours. When treating children in this way, the daily dose is calculated at 10–20 mg per kilogram of the child.
- Ointments - Lincomycin in the form of ointment is practically not used in dentistry. It is used more for treating skin. Apply two to three times a day to the affected area.
- The patch is the most convenient and easy to use - the Diplen-Denta-L patch. This is a self-adhesive plaster specially designed for dental treatment. One side of it consists of a hydrophilic layer for better contact with diseased gums. The second side is hydrophobic, which provides reliable protection against the penetration of unnecessary substances into the treatment area. This patch is attached to the gum for 6 or 8 hours and then carefully removed.
Contraindications
When prescribing a drug, it is important to take into account contraindications, when it is strictly prohibited to use this medicine:
- during pregnancy and during breastfeeding;
- in cases where there is increased sensitivity to the components of the drug;
- liver or kidney dysfunction.
infozuby.ru
Action
Lincomycin is a protein synthesis inhibitor.One of the most important elements in any living organism is protein, whose importance is difficult to exaggerate. Its significant lack causes protein starvation, which can lead to death. This law of nature has not bypassed the simplest microorganisms - bacteria, in which specialists have learned to suppress protein synthesis with the help of complex chemical compounds.
In the case of gram-positive bacteria, such an inhibitor of protein synthesis is Lincomycin, which in small concentrations suppresses the growth and development of microbes, and in large concentrations even destroys them. However, the drug still does not have any effect on other microorganisms, which significantly narrows its scope of application.
Composition and release forms
Lincomycin solutionDue to the variety of methods of treatment with Lincomycin, pharmacists produce the drug in several forms, the composition of which, although slightly, is still different. The basis for this is lincomycin hydrochloride, the concentration of which in most cases is 250-300 mg/g.
Solution
For intramuscular and intravenous injections, the drug is supplied in packages of 10 ampoules, each of which contains an aqueous solution of the main substance and auxiliary substances, represented by Trilon B and caustic soda.
Capsules
The drug is used orally in the form of capsules, produced in 10 pieces in one blister. Excipients in each capsule are:
- Aerosil;
- calcium stearate;
- cellulose.
Ointment
The medication is also used for application to the skin, which is due to the effective destruction of gram-positive bacteria on the outer integument of the body. The ointment is supplied in small tubes of 15 grams, and the excipients are:
- zinc oxide;
- potato starch;
- petroleum paraffin;
- medical Vaseline.
Lincomycin ointment Film
Available in the form of wipes impregnated with lincomycin hydrochloride, the concentration of which is in the range of 300-500 mg/g. In surgery, napkins measuring 7.5x10.5 cm are used, and in dentistry - 1x4 cm.
Indications
For diseases of the mouth and throat As a rule, this antibiotic is used against microbes that react to its action, which cause quite dangerous diseases. When bacteria settle in joints and bones, they can cause arthritis and osteomyelitis. Often the respiratory tract and ENT organs may be unprotected by the immune system, which can result in pneumonia, bronchitis, otitis media, lung abscess, pharyngitis and other diseases. In such cases, Lincomycin is prescribed (either orally or by injection), which actively destroys pathogenic bacteria.
Reviews describing Lincomycin in dentistry are given positive description antibiotic effect. As a rule, local injections are made in the oral cavity on the affected areas, but films are also used in the treatment of abscesses and fistulas. The antibiotic is effective in the complex treatment of various inflammations in the oral cavity: stomatitis, glossitis, gingivitis and other diseases.
Contraindications
Pregnant women should use the drug with caution Lincomycin has the ability to penetrate into all tissues of the body, including through the placenta. In this regard, the use of the drug during pregnancy is prohibited, as well as during lactation. If there is a need to treat a breastfeeding mother with this medication, then it is worth considering the issue of switching the child to another food.
Like all antibiotics, the drug must be gradually eliminated from the body, which is difficult in people with kidney or liver failure, as a result of which the harm from the drug can be much greater than the benefit, therefore, if the functions of the relevant organs are impaired, Lincomycin is not used.
Hypersensitivity to the components of the drug is also a contraindication - in this case, the medication should be replaced with an analogue.
It is also worth noting that the drug has side effects on the gastrointestinal tract, so if the digestive system is weak, the drug is prescribed very carefully.
Dosage
The attending physician, when prescribing a daily dose of medication, takes into account the patient’s age and the nature of the disease. Pharmacists give general recommendations for use, which can be found in the summary table. However, it is worth remembering that Lincomycin is an antibiotic and can only be used with a doctor’s prescription.
Lincomycin solution is also used intravenously, administered through a dropper, and orally at a dose of 0.5 g every 8 hours. If the patient missed the next time to take the medicine, then there is no need to panic: it is possible to do a period of more than 8 hours, the main thing is not less.
Overdose
Lincomycin accumulates in the body as a result of long-term use, which can cause the development of gastrointestinal candidiasis and pseudomemranous enterocolitis. If symptoms of these diseases occur, treatment with this medication is usually stopped. However, there have been no cases of acute drug poisoning in clinical medicine; most often complications take the form of increased side effects.
Side effects
Like all drugs of similar action, Lincomycin affects the gastrointestinal tract, often causing colitis. This is due to the fact that many bacteria live in the intestines, helping food to be absorbed, and with prolonged exposure to the medication they die, which causes significant difficulties in digestion. In this case, colitis can appear both during antibiotic therapy and 2-3 weeks after its completion.
Nausea is one of the side effects The drug often causes abdominal pain, nausea and vomiting, and changes liver function tests, characterized by a transient increase in the level of liver transaminases. The medication also reduces the level of leukocytes, neutrophils and platelets in the blood. As a rule, an allergic reaction occurs to the action of the antibiotic, which is expressed in dermatitis, urticaria, skin rashes and itching, and sometimes even anaphylactic shock can occur.
With rapid administration of the drug intravenously, the arterial pressure, skeletal muscles relax, dizziness occurs. When slow, the blood vessels become inflamed, provoking the development of phlebitis.
Analogues
Often, treatment can reach a dead end if pathogenic bacteria have developed resistance to the action of the drug. In this case, pharmacists have released many drugs that are similar in action, but different in composition, some of which (by no means all) are presented in the table.
An indication for replacement is also hypersensitivity to the active or excipients of the drug. However, it is worth remembering that the decision to replace Lincomycin can only be made by the attending physician.
Analogues have various shapes releases, the excipients in which differ significantly. You should read the detailed composition of the drugs in the instructions or consult a pharmacist, whose recommendations will help you avoid unwanted allergic reactions.
dr911.ru
Description of the drug, its types
In modern dentistry, Lincomycin can be used as a capsule, injection solution, ointment, and self-adhesive film.
Types of drug
- Ointment.
- Film.
- Solution for injection.
- Capsules.
The drug is also actively used to prevent such diseases.
The solution, as well as applying the product in the form of an ointment to the gums, are procedures prescribed by a doctor to combat microorganisms that contribute to the development of caries.
Dental practice involves the use of this drug after tooth extraction, since the product is able to prevent the addition of unwanted additional infections.
Diplene film is used as a local antibacterial agent.
The film is quite simply pasted onto any affected area of the oral cavity.
If the patient has periodontal disease, the dentist may prescribe the drug in the form of an injection.
The medicine can be used in conjunction with lidocaine, but this is more often observed with periodontitis.
It must be prescribed exclusively by a dentist, only in the correct dosage form and dosage.
Therefore, you need to familiarize yourself with the advantages, disadvantages, contraindications, as well as dosages characteristic of the drug.
Advantages and disadvantages
You should immediately pay attention to the advantages that lincomycin has, which significantly outweigh the disadvantages of the drug.
Advantages
- The antibiotic neutralizes microorganisms that are resistant to antibiotics.
- It is able to effectively fight staphylococci.
- Helps in the fight against viridans streptococcus, which is part of dental plaque, causing caries.
- A number of bacteria are unable to resist the effects of the drug in question.
- Lincomycin may remain effective for a long time.
- The accumulation of the drug in bone tissue helps to minimize the likelihood of the formation of purulent diseases in the future.
Among the disadvantages, it is perhaps worth highlighting its narrow spectrum of antimicrobial action.
Incorrect prescription of the drug or violation of the regime of its use prescribed by the treating dentist can lead to relapse of oral diseases.
When injecting the injection solution into the gum, you may feel discomfort, as with any injection.
These are all the disadvantages inherent in the antibiotic in question.
It is always a good idea to be informed regarding drug prices.
Prices for the drug in Moscow and the regions
- Solution g/chl 30% 1ml No. 10 amp. – 29 rubles (Moscow).
- Lincomycin hydrochloride capsules 250 mg 20 pcs – 41 rubles (Moscow).
- Lincomycin-akos ointment for external use pr. 2% 15 g – 38 rubles (Moscow).
- Ointment 2% 15 g – 23 rubles (Ekaterinburg).
- Ampoules 30% -1 ml – 37 rubles (Ekaterinburg).
- Lincomycin 300 mg/ml amp. 1 ml – 34 rubles (Chelyabinsk).
- Capsules. 250 mg – 37 rubles (Chelyabinsk).
Prices by region of the country are approximately the same.
It is worth noting that Diplene film costs between 390-460 rubles.
It is imperative to know about the indications, areas of application, and dosage of the drug.
Application in dentistry
- Ulcerative gingivitis.
- Small abscesses and fistulas.
- Various inflammatory diseases of the oral cavity.
- Osteomyelitis.
The method of using the product deserves special attention, and therefore it is worth understanding the dosage prescribed by a qualified specialist.
Instructions for taking the drug
- If necessary, take the drug in capsules - 3-4 times a day, 50 milligrams. Often, the duration of treatment ranges from 1-2 weeks, but with osteomyelitis, the duration of treatment can reach 3 weeks.
- Capsules are taken several hours before meals. You can take the medicine with liquid.
- Internal administration of the medicine - up to 2 times a day, 60 milligrams.
- Internal use of lincomycin hydrochloride by drip - several times a day, 600 milligrams.
- Medicine capsules for children are prescribed in a daily dosage calculated as 30-60 milligrams/kilogram of weight.
- If it is necessary to administer lincomycin hydrochloride - at intervals of 8-12 hours at a rate of 10-20 milligrams per 1 kg of weight.
- If there is a need for local administration of lincomycin ointment, the product is applied in a thin layer to the areas of the skin affected by the disease several times a day.
It is important to know! The ointment requires careful handling in the case of dermatomycosis, as well as fungal skin diseases.
Contraindications
- The drug is contraindicated in case of sensitivity to the ingredients medicine.
- During pregnancy and breastfeeding.
- For serious disorders of the liver and kidneys.
Thanks to this, it is possible to relieve the patient from many diseases oral cavity.
32norma.com
Analogues
- KMP-Lincomycin
- Lincomycin-Acos
- Lincomycin hydrochloride
- Lincocin
- Linosin
- Medoglycine
- Neloren
- Films with lincomycin
- Tsilimicin
Print a list of analogues
Dosage form
Capsules, lyophilisate for preparing a solution for intravenous and intramuscular administration, lyophilisate for preparing a solution for intramuscular administration, solution for intravenous and intramuscular administration, see. Also:
Lincomycin; ointment for external use
pharmachologic effect
The antibiotic produced by Streptomyces lincolniensis has a bacteriostatic effect. Suppresses bacterial protein synthesis due to reversible binding to the 50S ribosomal subunit and disrupts the formation of peptide bonds.
Active against gram-positive cocci (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.
Effective against Staphylococcus spp. resistant to penicillin, tetracyclines, chloramphenicol, streptomycin, cephalosporins (30% of Staphylococcus spp. resistant to erythromycin are cross-resistant to lincomycin).
Does not affect Enterococcus spp (including Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa; inferior in activity to erythromycin against spore-forming anaerobes, Neisseria spp., Corynebacterium spp.
The optimum action is in an alkaline environment (pH 8-8.5). Resistance to lincomycin develops slowly. In high doses it has a bactericidal effect.
Indications
Bacterial infections caused by sensitive microorganisms (primarily staphylococci and streptococci, especially microorganisms resistant to penicillins, as well as allergies to penicillins): sepsis, subacute septic endocarditis, chronic pneumonia, lung abscess, pleural empyema, pleurisy, otitis, osteomyelitis (acute and chronic), purulent arthritis, postoperative purulent complications, wound infection, skin and soft tissue infections (pyoderma, furunculosis, cellulitis, erysipelas).
Contraindications
Hypersensitivity, pregnancy (except in cases where it is necessary for “vital” indications), severe liver and/or kidney failure; lactation period, early infancy (up to 1 month). With caution. Fungal diseases skin, oral mucosa, vagina; myasthenia gravis (for parenteral administration).
Side effects
From the digestive system: nausea, vomiting, diarrhea, epigastric pain, abdominal pain, glossitis, stomatitis, transient hyperbilirubinemia, increased activity of “liver” transaminases; with long-term use – gastrointestinal candidiasis, pseudomembranous enterocolitis.
From the hematopoietic organs: reversible leukopenia, thrombocytopenia, neutropenia.
Allergic reactions: urticaria, exfoliative dermatitis, angioedema, anaphylactic shock.
Local reactions: with intravenous administration - phlebitis.
With rapid intravenous administration - decreased blood pressure, dizziness, asthenia, relaxation of skeletal muscles.
Application and dosage
Parenteral: i.v., i.m., orally.
The daily dose for adults when administered parenterally is 1.8 g, single dose is 0.6 g. In case of severe infection, the daily dose can be increased to 2.4 g (in 3 doses with an interval of 8 hours).
IV, children - in a daily dose of 10-20 mg/kg, regardless of age. IV – drip only, at a rate of 60-80 drops/min. Before administration, 2 ml of a 30% solution (0.6 g) is diluted with 250 ml of a 0.9% NaCl solution.
Inside, 1-2 hours before meals. For adults, the daily dose is 1-1.5 g, single dose is 0.5 g. For children, the daily dose is 30-60 mg/kg.
The duration of treatment, depending on the form and severity of the disease, is 7-14 days (for osteomyelitis - 3 weeks or more).
For long-term or repeated courses, treatment should be carried out under monitoring of liver and kidney function.
In case of renal and hepatic failure, it should be used parenterally in a daily dose not exceeding 1.8 g, with an interval between doses of at least 12 hours.
special instructions
To avoid the development of thrombophlebitis and aseptic necrosis, it is better to administer it deeply intramuscularly.
It cannot be administered intravenously without prior dilution.
During long-term treatment, periodic monitoring of the activity of liver transaminases and kidney function is necessary.
Prescription to patients with liver failure is permissible only for “vital” indications.
The parenteral form, containing benzyl alcohol, can lead to the development of bronchospasm in premature infants.
If signs of pseudomembranous enterocolitis appear (diarrhea, leukocytosis, fever, abdominal pain, discharge of blood and mucus with feces), in mild cases it is sufficient to discontinue the drug and prescribe ion exchange resins (cholestyramine); in severe cases, replacement of loss of fluid, electrolytes and protein is indicated, vancomycin - orally, in a daily dose of 0.5-2 g (in 3-4 doses) for 10 days or bacitracin.
Interaction
Pharmaceutically incompatible with kanamycin, ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate.
Antagonism - with erythromycin, synergism - with aminoglycosides.
Antidiarrheal drugs reduce the effect.
Strengthens the neuromuscular blockade caused by muscle relaxants (especially when administered parenterally).
www.analogitabletok.ru
Indications for use of Lincomycin
A list of everything that lincomycin is used for in dentistry includes a large number of points. This drug is indicated for the following situations or illnesses:
- herpes;
- dental implantation;
- periostitis with abscesses and fistulas;
- bleeding and inflammation of gums, teeth and their roots;
- purulent accumulations in periodontal pockets;
- severe ulcerative gingivitis;
- osteomyelitis;
- periodontal disease;
- alveolitis;
- periodontitis;
- caries.
In addition, lincomycin is used in dentistry to relieve swelling after tooth extraction or cleansing enamel of stones. Such events often lead to inflammatory processes that require immediate treatment. Antibiotics after tooth extraction reduce the risk of such consequences, which also applies to Lincomycin. In addition to existing diseases, the drug is used to prevent them, for example, after surgery. As a dental anesthetic, lincomycin is used in dentistry together with lidocaine.
Instructions for use
The dental antibiotic "Lincomycin" has several release forms that are convenient to use for a particular dental disease:
- Ointment. In addition to treating gums, it is used in the fight against herpes to neutralize viruses and bacteria.
- Solution for injection, intramuscular and intravenous. In this form, the drug is used in difficult cases, for example, in the destruction of bone tissue.
- Tablets, capsules. Taken orally as an analgesic or anti-inflammatory, for example, after wisdom tooth removal.
- Patch. It is used for both dental and orthopedic or surgical purposes. The drug itself consists of 2 layers - hydrophilic and hydrophobic. The first is resistant to moisture, and the second protects the damaged area from hazardous substances. This form of the drug is very convenient to use - the film is glued to the damaged area for 6-8 hours and then removed.
Lincomycin ointment
The ointment is called Lincomycin Akos. Refers to antibiotics belonging to the group of lincosamides. It has a bactericidal effect due to the suppression of protein synthesis in the bacterial cell. It should be used up to 3 times daily, spreading a thin layer over the inflamed gums or applying compresses with a soaked cotton swab. It is recommended to use it carefully for those diagnosed with dermatomycosis or other fungal skin infections. The price of a tube with 2% ointment weighing 15 g ranges from 30 to 50 rubles.
Ukolov
Lincomycin in ampoules is administered intravenously or intramuscularly. Indicated for more severe forms of dental disease. The package contains 5, 10 or 100 ampoules. Their price is from 50 rubles. Lincomycin hydrochloride solution is administered in the following dosage:
- intramuscularly - 600 mg for adults twice a day and 10-20 mg for children per 1 kg of weight;
- intravenously - up to 3 times daily, 600 mg, diluted with 250-300 ml of glucose solution or sodium chloride.
Tablets
This form of "Lincomycin" is a white-yellow capsule. Each contains 250 mg of powder. Packages are available in 10, 20 and 360 tablets. The dosage for adults should not exceed 500 mg. You need to take 3 or 4 times every day. For children from one month to 14 years of age, the dose is calculated as 30-60 mg per kilogram of weight. Treatment can last 1-2 weeks. The exception is osteomyelitis. For him, the course of therapy lasts 3 or more weeks. It is recommended to swallow the capsule several hours before meals with big amount water. Price from 170 rub.
Features of the use of antibiotics in dentistry
The difference between this drug is that its absorption depends on the amount eaten before the meal. On an empty stomach, the absorption of the medicine reaches 30%. For comparison, after eating this figure decreases to 5%, and this concentration has absolutely no effect. "Lincomycin" is not used for inhalation anesthesia, allergic reaction, with medications to relax the muscles. Similarly, you should not drink alcohol while treating with the drug.
After tooth extraction
Lincomycin is used in dentistry to speed up wound healing after tooth extraction and prevent infection. Without an antibiotic, the risk of developing inflammation and tumors increases, especially if a person rinses the mouth vigorously immediately after the procedure, and the doctor did not warn about the consequences of such actions. After 2-3 days, the pain begins to increase, and the wound itself becomes inflamed. This complication is called alveolitis. To avoid it, after washing and suturing the hole, the doctor prescribes taking “Lincomycin” for 5 days, 1 capsule three times a day.
For toothache
If patients are allergic to penicillin, Lincomycin is used. The correct dosage of the drug stops the proliferation of bacteria, strengthens the enamel, and eliminates the inflammatory process that causes pain. The medicine begins to work 40 minutes after administration. It is not recommended to use the drug to relieve toothache during pregnancy or breastfeeding. It should not be used by people intolerant to Lincomycin or Clindamycin.
For inflammation of gums and teeth
For treatment inflammatory diseases In the oral cavity, injections in ampoules are more often used. "Lincomycin" is effective for problems with the ligaments with which the teeth are held in their socket. Besides, beneficial effect the drug has an effect on inflamed periodontal tissues. An antibiotic solution is used for serious purulent inflammations, which are characterized by damage to the jaw bones.
With flux
A feature of the use of the antibiotic “Lincomycin” for flux is that you cannot stop taking it even with some improvements. It is necessary to complete the prescribed course to avoid the development of gum abscess and phlegmon, shown in the photo. Together with Lincomycin, the doctor may prescribe anti-inflammatory, decongestant or painkillers. Among these are Diazolin, Diclofenac and the drug Nimesil.
Analogues
Any medicine has more modern analogues that can be taken in case of intolerance or other restrictions:
- "Ekolinkom". It is also an antibiotic of the lincosamide group. Indicated for wound infection, osteomyelitis, sepsis. The dosage is 0.5 g 2-3 times daily 2 hours before meals. Price from 200 rub.
- "Neloren." Antibiotic of the lincomycin group. Indicated for skin infections and inflammation of soft tissues. Produced in tablets or ampoules. It is necessary to take 0.5 g up to 4 times daily before meals. Price from 80 rub.
- "Clindamycin." Belongs to the lincosamide group. Used for osteomyelitis, infectious and inflammatory diseases. The medication is taken 1 tablet at intervals of 6 hours, but no more than 4 times a day. Price from 160 rub.
- "Lincocin." A drug from the group of lincosamide antibiotics. The pharmacy can offer both tablets and injection solution. The daily dose for adults is 1.8 g. It must be divided into 3 times, i.e. 0.6 g each. Price from 100 rub.
This page provides a list of all Lincomycin analogues by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.
- The cheapest analogue of Lincomycin:
- The most popular analogue of Lincomycin:
- ATX classification: Lincomycin
- Active ingredients/composition: lincomycin
Cheap analogs of Lincomycin
| # | Name | Price in Russia | Price in Ukraine |
|---|---|---|---|
| 1 | lincomycin | 58 RUR | 20 UAH |
| 2 | clindamycin | 110 rub. | 26 UAH |
| 3 | lincomycin Analogue in composition and indication | 165 RUR | 205 UAH |
| 4 | clindamycin Similar in indication and method of use | 411 RUR | 14 UAH |
| 5 | clindamycin Similar in indication and method of use | 1318 RUR | 14 UAH |
When calculating the cost cheap analogs of Lincomycin the minimum price was taken into account, which was found in the price lists provided by pharmacies
Popular analogues of Lincomycin
The list of drug analogues based on statistics of the most requested drugs
All analogs of Lincomycin
The above list of drug analogues, which indicates Lincomycin substitutes, is the most suitable because they have the same composition of active ingredients and coincide in indications for use
Analogues by indication and method of use
Different composition, may have the same indication and method of use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| erythromycin | 10 rub | 4 UAH |
| erythromycin | -- | 15 UAH |
| spiramycin | 744 RUR | 7 UAH |
| spiramycin | -- | -- |
| spiramycin | -- | 147 UAH |
| midecamycin | 176 RUR | 35 UAH |
| oleandomycin phosphate, tetracycline | -- | -- |
| roxithromycin | -- | -- |
| roxithromycin | 288 RUR | -- |
| Roxithromycin | 2490 RUR | -- |
| roxithromycin | -- | 54 UAH |
| josamycin | 174 RUR | 127 UAH |
| josamycin | 532 RUR | 127 UAH |
| -- | 65 UAH | |
| clarithromycin | 238 RUR | 72 UAH |
| 200 rub | -- | |
| clarithromycin | 68 RUR | 42 UAH |
| -- | -- | |
| clarithromycin | 191 RUR | 144 UAH |
| clarithromycin | -- | 273 UAH |
| -- | -- | |
| clarithromycin | 84 RUR | 55 UAH |
| clarithromycin | 167 RUR | 88 UAH |
| 238 RUR | 34 UAH | |
| clarithromycin | -- | 137 UAH |
| clarithromycin | -- | -- |
| clarithromycin | -- | 39 UAH |
| clarithromycin | -- | -- |
| clarithromycin | -- | 170 UAH |
| clarithromycin | 1959 RUR | -- |
| clarithromycin | -- | 74 UAH |
| clarithromycin | -- | 83 UAH |
| clarithromycin | -- | 45 UAH |
| clarithromycin | -- | -- |
| clarithromycin | 264 RUR | 189 UAH |
| clarithromycin | 449 RUR | 112 UAH |
| -- | 90 UAH | |
| -- | 25 UAH | |
| -- | 25 UAH | |
| -- | -- | |
| -- | -- | |
| -- | 133 UAH | |
| clarithromycin | 195 RUR | -- |
| clarithromycin | 179 RUR | 420 UAH |
| clarithromycin | 195 RUR | -- |
| clarithromycin | -- | -- |
| clarithromycin | -- | -- |
| clarithromycin | 398 RUR | -- |
| Azithromycin dihydrate | -- | 69 UAH |
| Azithromycin | -- | 41 UAH |
| Azithromycin | -- | 48 UAH |
| azithromycin | -- | -- |
| azithromycin | 168 RUR | 70 UAH |
| azithromycin | 81 RUR | 59 UAH |
| azithromycin | 17 RUR | 15 UAH |
| -- | -- | |
| Azithromycin | -- | 49 UAH |
| azithromycin | 24 rub. | -- |
| -- | 26 UAH | |
| azithromycin | -- | 363 UAH |
| azithromycin | -- | 38 UAH |
| itraconazole | -- | -- |
| azithromycin | 38 rub. | 50 UAH |
| azithromycin | 58 RUR | 55 UAH |
| -- | 92 UAH | |
| -- | 27 UAH | |
| azithromycin | -- | 78 UAH |
| azithromycin | -- | 31 UAH |
| azithromycin | -- | 87 UAH |
| azithromycin | -- | 69 UAH |
| azithromycin | -- | 44 UAH |
| azithromycin | 200 rub | 50 UAH |
| -- | -- | |
| -- | -- | |
| -- | 67 UAH | |
| -- | 49 UAH | |
| -- | 49 UAH | |
| -- | 59 UAH | |
| -- | 93 UAH | |
| -- | -- | |
| 208 RUR | -- | |
| azithromycin | 267 RUR | -- |
| azithromycin dihydrate | 152 rub. | 39 UAH |
| azithromycin | -- | -- |
| azithromycin | 60 rub | -- |
| azithromycin | 267 RUR | 435 UAH |
| azithromycin | -- | -- |
| azithromycin | -- | -- |
| Pristinamycin | 4990 rub. | -- |
To compile a list of cheap analogues of expensive drugs, we use prices that are provided to us by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up to date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find everything possible options analogues of the sought-after medicine, as well as prices and addresses of pharmacies where it is available.
How to find a cheap analogue of an expensive medicine?
To find an inexpensive analogue of a medicine, a generic or a synonym, first of all we recommend paying attention to the composition, namely the same active ingredients and indications for use. The same active ingredients of a drug will indicate that the drug is a synonym for the drug, pharmaceutically equivalent or a pharmaceutical alternative. However, we should not forget about the inactive components of similar drugs, which may affect safety and effectiveness. Do not forget about the instructions of doctors; self-medication can harm your health, so always consult a doctor before using any medication.Lincomycin price
Use the websites below to find prices for Lincomycin and find out availability at your local pharmacy.Lincomycin instructions
Composition and release forms
Capsules.Lincomycin (in the form of hydrochloride monohydrate): 1 drop. - 250 mg. 10 pcs. - contour cell packaging (2) - cardboard packs.
pharmachologic effect
Antibiotic of the lincosamide group. In therapeutic doses it acts bacteriostatically. At higher concentrations it has a bactericidal effect. Suppresses protein synthesis in microbial cells. Active primarily against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae /except Enterococcus faecalis/), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp. Lincomycin is also active against Mycoplasma spp. Most gram-negative bacteria, fungi, viruses, and protozoa are resistant to lincomycin. Resistance develops slowly. Cross-resistance exists between lincomycin and clindamycin.
Interaction
At simultaneous use with penicillins, cephalosporins, chloramphenicol or erythromycin, antagonism of the antimicrobial action is possible. When used simultaneously with aminoglycosides, synergism of action is possible. When used simultaneously with inhalation anesthesia or peripherally acting muscle relaxants, an increase in neuromuscular blockade is observed, up to the development of apnea. Taking antidiarrheal drugs reduces effect of lincomycin. Pharmaceutical interactions Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate. Lincomycin is incompatible in the same syringe or dropper with kanamycin or novobiocin.
Pharmacokinetics
After oral administration, 30-40% is absorbed from the gastrointestinal tract. Eating slows down the rate and extent of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates through the placental barrier. Partially metabolized in the liver. T1/2 is about 5 hours. It is excreted unchanged and in the form of metabolites in urine, bile and feces.
Clinical pharmacology
Active substance: lincomycin. An antibiotic of the lincomycin (lincosamide) group, produced Streptomyces lincolnensis or other related actinomycetes. White or almost white crystalline powder with a bitter taste. Easily soluble in water, difficult in alcohol. Suppresses protein synthesis of bacteria due to reversible binding to the 50S subunit of ribosomes, disrupts the formation of peptide bonds. Effective against gram-positive microorganisms ( Staphylococcus spp., Streptococcus spp., incl. Streptococcus pneumoniae,Corynebacterium diphtheriae), some anaerobic spore-forming bacteria ( Clostridium spp.) and gram-negative anaerobes ( Bacteroides spp.,Mycoplasma spp.). Acts on microorganisms (especially Staphylococcus spp.), resistant to other antibiotics. Not sensitive to lincomycin Enterococcus spp.(incl. Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa. Inferior in activity to erythromycin against spore-forming anaerobes, Neisseria spp., Corynebacterium spp. Resistance develops slowly. Cross-resistance exists between lincomycin and clindamycin. At therapeutic doses it has a bacteriostatic effect, at higher doses and against highly sensitive microorganisms it has a bactericidal effect. When taken orally on an empty stomach, approximately 20–30% of the dose is absorbed (food intake significantly reduces absorption, bioavailability when taken after meals is 5%), Cmax in blood is reached in 2–4 hours. It is well and quickly distributed into most tissues and body fluids (except cerebrospinal fluid), high concentrations are created in bile and bone tissue. Does not pass through the BBB well. It quickly passes through the placenta, concentrations in the fetal blood serum are 25% of the concentration in the maternal blood. Passes into breast milk. Metabolized in the liver. T1/2 with normal renal function is 4–6 hours, with end-stage kidney disease - 10–20 hours, with impaired liver function T1/2 increases by 2 times. It is excreted unchanged and in the form of metabolites with bile and kidneys. When taken orally, 30–40% of the dose is excreted unchanged in feces within 72 hours. Hemodialysis and peritoneal dialysis are not effective in removing lincomycin from the body.
Directions for use and doses
When taken orally by adults - 500 mg 3-4 times a day or intramuscularly - 600 mg 1-2 times a day. 600 mg is administered intravenously in 250 ml of isotonic sodium chloride or glucose solution 2-3 times a day. Children aged 1 month to 14 years orally - 30-60 mg/kg/day; Injected intravenously at a dose of 10-20 mg/kg every 8-12 hours. For external use, apply a thin layer to the affected areas of the skin.
Side effects
From the digestive system: nausea, vomiting, epigastric pain, diarrhea, glossitis, stomatitis; transient increase in the level of liver transaminases and bilirubin in the blood plasma; with long-term use in high doses, the development of pseudomembranous colitis is possible. From the hematopoietic system: reversible leukopenia, neutropenia, thrombocytopenia. Allergic reactions: urticaria, exfoliative dermatitis, Quincke's edema, anaphylactic shock. Effects due to chemotherapeutic action: candidiasis. Local reactions: phlebitis (with intravenous administration). With rapid intravenous administration: decreased blood pressure, dizziness, general weakness, relaxation of skeletal muscles.
Overdose
In case of an overdose of lincomycin, increased side effects may occur. Symptomatic therapy is necessary. Lincomycin is not removed from the body during hemodialysis and peritoneal dialysis. With prolonged use of lincomycin, candidiasis may develop. gastrointestinal tract, pseudomembranous enterocolitis, if the latter develops, it is necessary to stop taking lincomycin.
special instructions
If liver and/or kidney function is impaired, the single dose of lincomycin should be reduced by 1/3-1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of renal and liver functions is necessary. In case of development of pseudomembranous colitis, lincomycin should be discontinued and vancomycin or bacitracin should be prescribed.
Storage
Store at room temperature.
All information is presented for informational purposes and is not a reason for independent prescription or replacement of medication.Lincomycin ointment has strong bactericidal and bacteriostatic properties. These qualities of the drug are used in the treatment of dermatological diseases that are complicated by infectious and inflammatory processes caused by pathogenic microorganisms.
The drug effectively frees the affected areas of the skin from bacteria and promotes their rapid recovery.
Lincomycin ointment is widely used in medical practice thanks to carefully selected composition, the ability to use it for a long period and a small number of side effects.
The drug is used both independently and as part of complex therapy, which is most effective in treating severe cases of skin infections or weak immunity of the patient.
Composition and release form
Lincomycin ointment has high medicinal properties. It helps eliminate inflammation in a short time and accelerate the healing of the damaged surface.
High efficiency provided by the active component included in the composition - lincomycin hydrochloride. The drug's excipients help enhance the effect of the drug: lanolin, purified paraffin, medical petroleum jelly, glycerin, potato starch and zinc oxide, which relieves inflammation and has a drying property.
How does Lincomycin ointment work?
Lincomycin has an active bacteriostatic influence. As a result of the action of the active substance, the spread of pathogenic microorganisms stops. In high concentrations, the drug completely neutralizes the inflammatory focus.
When applied, the drug is quickly absorbed and the effect of the active substance on pathogenic microflora begins. The positive results of using the product are noticeable after the first applications.
The active substance helps get rid of advanced forms lesions skin, affecting the production of protein necessary for the growth and development of pathogenic bacteria. After the destruction of cells of pathogenic microorganisms, the epidermis is cleansed.
The drug is active against various types pathogenic bacteria, some types of fungi and protozoan microorganisms. The action of Lincomycin does not apply to fungi, viruses and gram-negative bacteria.
The active effect of the drug is ensured due to its good absorbency into the skin and rapid breakdown. Residues of the drug are eliminated from the body by the kidneys and intestines.
If the instructions and prescriptions of the attending physician are strictly followed, the active substance does not accumulate in the body. However, for a favorable treatment outcome, it is not recommended to use the product for more than two weeks.
Indications for use
The use of the drug is carried out only as prescribed by a dermatologist after an accurate diagnosis. The use of ointment is recommended for bacterial skin lesions, which are complicated by inflammation, swelling and purulent lesions.
Lincomycin ointment is used for antibacterial treatment the following diseases skin:
To enhance the therapeutic effect, in some cases Lincomycin ointment is used in conjunction with other forms of this drug.
According to the instructions for use, the use of the drug is strictly prohibited if the patient has chronic liver and kidney diseases. The drug should not be used in cases of hypersensitivity to the components of the drug, as well as during pregnancy and breastfeeding.
Lincomycin ointment is not used for treatment children under one month old.
The product should be used with caution for fungal diseases and dermatomycoses, since the drug may cause side effects such as allergies or skin irritation.
Lincomycin ointment: instructions for use and dosage
Lincomycin ointment is intended for external use. The drug is applied in a thin layer to the previously peeled surfaces.
The duration of treatment depends on the body's sensitivity to the active component and, as a rule, is 10-12 days.
The use of the drug to treat a child should be under the supervision of a pediatrician. This is due to the increased sensitivity of children's skin. It is acceptable to use the ointment 1-2 times for 5-7 days.
The use of the drug for the treatment of newborns is contraindicated.
Use of Lincomycin ointment during pregnancy forbidden manufacturer of the drug. The active substance is able to overcome the placental barrier and provide negative impact for the fruit.
Side effects
With an independent increase in dosage or duration of use of the drug, patients may experience the following: negative consequences:
- exacerbation of signs of the underlying disease;
- increased sensitivity of the skin;
- muscle weakness;
- drowsiness;
- lowering blood pressure.
In these cases, use of the product should be discontinued.
special instructions
According to the instructions, the drug should be used carefully when treating elderly patients, as they may experience negative reactions from the skin. If an allergic reaction occurs, the area where the product is used should be cleaned of drug residues and rinsed with plenty of warm water.
Lincomycin ointment is an active antibiotic, intended for local use. As part of complex treatment, its effectiveness does not decrease when interacting with other drugs.
Drinking alcohol during therapy with the drug is unacceptable, as it makes it difficult to absorb the active substance.
Analogs of Lincomycin ointment
A number of ointments intended for external use have a similar effect: Levomekol, Ichthyol ointment, Vishnevsky Liniment. In some cases, Lincomycin ointment can be replaced with Helimycin ointment, which has a similar effect.
Analogues include Baneocin, Betaderm, Tobradex.
Price
The medicine can be bought at a pharmacy without a doctor's prescription. The average cost of a package of the drug ranges from 50 to 120 rubles, depending on the pharmacy.
